Endocrine Abstracts

Section 1: Case history: 75 year old female diagnosed with Grade 1 pNET (Ki-67 index 70%) in 2018. Treated with subtotal pancreatectomy but 8 months post-surgery a follow up scan showed new liver metastases, at which point she was commenced on lanreotide. 3 months later she presented with an 8 week history of episodic weakness, sweating and confusion consistent with hypoglycaemia. These episodes initially improved with eating but had become more severe and unresponsive to carb...

Long acting somatostatin analogues (SSA) such as Sandostatin LAR and Lanreotide Autogel are the most commonly used drugs in the management of neuroendocrine tumours (NETs) due to their ability to control symptoms and prolong survival. SSAs use is associated with changes in glucose metabolism. However, there is lack of data for such effects in patients with NETs. We evaluated the effects of SSA on BMI and HbA1c in our cohort of patients with NETs.Methods:...

Background: An increasing amount of biomedical data is becoming available, and methods are needed to tackle these “big data”.Methods: We performed a systematic evaluation of 138 environmental and behavioral factors in relation to bone mineral density (BMD) in the National Health and Nutrition Examination Survey (NHANES). Dual energy X-ray absorptiometry (DXA) scans were available for total body, head, pelvis and lumbar spine for 27,259 particip...

Introduction: Morbid obesity has serious associated co morbidities and is an independent risk factor for ischaemic heart disease. Obesity together with low functional status and exercise tolerance makes pre-operative cardiac assessment difficult and patients with few cardiac risk factors are often referred for cardiac assessment. This can not only be burdensome to services and prolongs waiting times for surgery but can also cause patient anxiety and poor compliance.<p clas...

Introduction: Standard endoscopic resection of rectal neuroendocrine tumours (NETs) is often associated with histological incomplete excision due to the submucosal position of the tumour within the bowel. This can lead to multiple attempts to achieve a complete excision or uncertainty leading to ongoing endoscopic surveillance. Endoscopic full thickness resection may allow early definitive management. We report a simple definitive technique for the full thickness excision of r...

Background and aims: Polycystic Ovary syndrome (PCOS) is a common, lifelong condition. Its associated symptoms have been linked with psychological consequences, but less attention has been given to the daily implications of living with the condition. We aimed to explore women’s experiences of living with PCOS, including a specific focus on practical implications and methods of providing support such as structured group-based patient education.Method...

Background: The benefits of patient education in women with polycystic ovary syndrome (PCOS) are known but a cost effective way to offer the education to these patients need to be assessed. As part of a quality improvement project in an outpatient setting we tested the idea of incorporating group education for women with PCOS in their routine care process. We tested two different methods.Methods: 1. January-June 2017: Ad hoc open patient invitation<p...

Background: Most cases of hypopituitarism are due to pituitary tumours or their treatment. Surgery is the treatment of choice in cases of pituitary adenomas which account for 90% of sellar and parsellar lesions. We present an unusual case of a non-adenomatous pituitary mass presenting with panhypopituitarism.Case: A 56-year-old male with background of sickle cell trait and hypertension presented with syncope, lethargy and nausea. He had an 18-month histo...

Background: Childhood obesity is a growing problem worldwide, with serious effects on child health. Obese children are at a higher risk of developing metabolic co-morbidities earlier in life (WHO, 2013). Manchester has worse than national average levels of obesity, with an estimated 14 000 obese children (PHE, 2014).Aims and methods: A retrospective case note analysis of 117 obese paediatric patients, seen in our service between March 2012 and 2014, was ...

Introduction: The length of patient survival after cancer treatment is increasing and, in some cases, does not differ from the average life span in healthy individuals. The aim of the study is to evaluate thyroid function after oncologic treatment in children.Description of Methods: A group of 158 patients aged 16–25 who underwent oncologic treatment in childhood and the control group – 66 children and young adults were examined. The prospectiv...